This study investigates the genetic determinants and phenotypic consequences of T-cell abundance in over 200,000 individuals from diverse ancestries. Using whole genome sequencing data, the researchers identified 27 loci associated with T-cell fraction and found significant correlations with sex, age, and ancestry. Analysis of electronic health records revealed associations between T-cell fraction and respiratory diseases. The study provides insights into the genetic regulation of T-cells and their role in human health.
Publisher
Nature Communications
Published On
Nov 16, 2024
Authors
Hannah Poisner, Annika Faucon, Nancy Cox, Alexander G. Bick
