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Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

Medicine and Health

Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

H. Poisner, A. Faucon, et al.

This study, conducted by Hannah Poisner, Annika Faucon, Nancy Cox, and Alexander G. Bick, delves into the intricate genetic regulation of T-cells, uncovering 27 loci linked to T-cell abundance across varied ancestries. Their findings reveal significant connections between T-cell fractions and health outcomes, particularly respiratory diseases.

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Playback language: English
Abstract
This study investigates the genetic determinants and phenotypic consequences of T-cell abundance in over 200,000 individuals from diverse ancestries. Using whole genome sequencing data, the researchers identified 27 loci associated with T-cell fraction and found significant correlations with sex, age, and ancestry. Analysis of electronic health records revealed associations between T-cell fraction and respiratory diseases. The study provides insights into the genetic regulation of T-cells and their role in human health.
Publisher
Nature Communications
Published On
Nov 16, 2024
Authors
Hannah Poisner, Annika Faucon, Nancy Cox, Alexander G. Bick
DOI
https://doi.org/10.1038/s41467-024-51095-1
Tags
T-cell abundance
genetic determinants
whole genome sequencing
respiratory diseases
ancestors
health records
phenotypic consequences

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