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Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

Medicine and Health

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

A. Maifeld, H. Bartolomaeus, et al.

This groundbreaking study explores how a 5-day fast followed by a modified DASH diet can significantly improve health outcomes for hypertensive metabolic syndrome patients. Conducted by a team of experts including András Maifeld and Hendrik Bartolomaeus, the research reveals impressive reductions in blood pressure and body mass index at three months post-intervention. Additionally, insights into gut microbiome alterations shed light on the relationship between diet and long-term health.

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Playback language: English
Abstract
This study investigated the effects of a 5-day fast followed by a modified Dietary Approach to Stop Hypertension (DASH) diet on hypertensive metabolic syndrome patients. Results showed that this intervention reduced systolic blood pressure, need for antihypertensive medications, and body mass index at three months post-intervention compared to a modified DASH diet alone. Fasting altered the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Machine learning analysis predicted sustained systolic blood pressure response based on baseline immunome or microbiome data.
Publisher
Nature Communications
Published On
Mar 30, 2021
Authors
András Maifeld, Hendrik Bartolomaeus, Ulrike Löber, Ellen G. Avery, Nico Steckhan, Lajos Markó, Nicola Wilck, Ibrahim Hamad, Urša Šušnjar, Anja Mähler, Christoph Hohmann, Chia-Yu Chen, Holger Cramer, Gustav Dobos, Till Robin Lesker, Till Strowig, Ralf Dechend, Danilo Bzdok, Markus Kleinewietfeld, Andreas Michalsen, Dominik N. Müller, Sofia K. Forslund
Tags
hypertension
metabolic syndrome
DASH diet
fasting
gut microbiome
blood pressure
body mass index

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