Medicine and Health

Cumulative muscle mass and blood pressure but not fat mass drives arterial stiffness and carotid intima-media thickness progression in the young population and is unrelated to vascular organ damage

A. O. Agbaje, A. R. Barker, et al.

This longitudinal study by Andrew O. Agbaje, Alan R. Barker, and Tomi-Pekka Tuomainen explores how fat mass, lean mass, and blood pressure from childhood to young adulthood influence arterial health. Notably, while lean mass and blood pressure correlate positively with carotid artery changes, fat mass shows no link. Discover the critical findings that could reshape our understanding of young adult cardiovascular health!

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Abstract

This longitudinal study examined the associations of fat mass, lean mass, and blood pressure (BP) from childhood to young adulthood with changes in carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT). Using data from 3863 participants in the Avon Longitudinal Study of Parents and Children, researchers found that cumulative high lean mass, systolic BP, and diastolic BP were positively associated with increased cfPWV. Persistent high lean mass, BMI, and systolic BP were associated with thicker cIMT. Total and trunk fat mass showed no association with cfPWV or cIMT progression. Increased lean mass and BP, but not fat mass, drive arterial remodeling in young adulthood.

Publisher

Springer Nature

Published On

Oct 14, 2022

Authors

Andrew O. Agbaje, Alan R. Barker, Tomi-Pekka Tuomainen

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