Medicine and Health

Effect of fruits granola (Frugra®) consumption on blood pressure reduction and intestinal microbiome in patients undergoing hemodialysis

H. Nagasawa, S. Suzuki, et al.

This groundbreaking study by Hajime Nagasawa and colleagues uncovers the promise of fruit granola (FGR) for hemodialysis patients. Over two months, FGR consumption led to significant reductions in blood pressure, serum indoxyl sulfate levels, and improved gut microbiome diversity. Discover how such dietary changes could be crucial in battling cardiovascular diseases in this vulnerable population.

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Abstract

Cardiovascular diseases (CVDs) are a leading cause of death among hemodialysis (HD) patients. This study investigated the effects of fruits granola (FGR) consumption on blood pressure (BP), serum indoxyl sulfate (IS) levels, and the intestinal microbiome in HD patients. Twenty-four HD patients consumed FGR for two months. Results showed significant decreases in systolic and diastolic BP, estimated salt intake, and serum IS levels. Gut microbiota analysis revealed increased alpha diversity and abundances of *Blautia* and *Neglecta*, along with increased lactic acid- and ethanol-producing bacteria and decreased indole-producing bacteria. FGR consumption may be beneficial for reducing CVD risk factors in HD patients.

Publisher

Springer Nature

Published On

Sep 19, 2024

Authors

Hajime Nagasawa, Shogo Suzuki, Takashi Kobayashi, Tomoyuki Otsuka, Teruyuki Okuma, Satoshi Matsushita, Atsushi Amano, Yoshio Shimizu, Yusuke Suzuki, Seiji Ueda

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