Medicine and Health

Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis

L. N. Codd, D. G. Blackmore, et al.

This exciting research conducted by Lavinia N. Codd, Daniel G. Blackmore, Jana Vukovic, and Perry F. Bartlett explores the remarkable link between exercise-induced neurogenesis and cognitive recovery in mice with hippocampal injury. Discover how voluntary wheel running significantly reversed spatial learning deficits, revolutionizing our understanding of brain recovery mechanisms!

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Index

Abstract

Hippocampal atrophy and cognitive decline are common consequences of neurodegenerative diseases. This study investigated whether exercise-induced neurogenesis could improve cognitive function in mice with unilateral hippocampal injury. Mice with endothelin-1 (ET-1)-induced hippocampal lesions exhibited significant spatial learning deficits. Voluntary wheel running for 21 days almost completely reversed these deficits, an effect linked to increased neurogenesis in both the injured and contralateral hippocampi. Ablation of newborn neurons eliminated the cognitive improvement, demonstrating the crucial role of neurogenesis in recovery.

Publisher

Scientific Reports

Published On

Nov 06, 2020

Authors

Lavinia N. Codd, Daniel G. Blackmore, Jana Vukovic, Perry F. Bartlett

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