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Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

Biology

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

D. D. Biase, F. Cappadocio, et al.

Discover how Escherichia coli glutamate decarboxylase (EcGadB) transforms a unique phosphinic analog of glutamate into a metabolite with promising implications for prodrug design. This fascinating research was conducted by Daniela De Biase, Francesca Cappadocio, Eugenia Pennacchietti, Fabio Giovannercole, Antonio Coluccia, Jouko Vepsäläinen, and Alex Khomutov.

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