Medicine and Health

Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

J. M. Gammon, S. T. Carey, et al.

Discover how a groundbreaking study by Joshua M. Gammon and colleagues harnesses the potential of intra-lymph node injection using degradable microparticles to achieve antigen-specific tolerance in autoimmune diseases. This innovative approach targets type 1 diabetes and allograft rejection, offering a promising strategy for lasting immunity without the risks of non-specific immunosuppression.

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Playback language: English

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Abstract

Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune disease and allograft rejection. This study uses intra-lymph node injection of diffusion-limited degradable microparticles encapsulating self-antigens with rapamycin to potently inhibit disease in pre-clinical type 1 diabetes and allogenic islet transplantation models. The efficacy depends on both antigen and rapamycin, leading to antigen-specific regulatory T cell expansion and the development of tolerogenic lymph node microdomains. This approach promotes durable tolerance without non-specific immunosuppression.

Publisher

Nature Communications

Published On

Feb 08, 2023

Authors

Joshua M. Gammon, Sean T. Carey, Vikas Saxena, Haleigh B. Eppler, Shannon J. Tsai, Christina Paluskievicz, Yanbao Xiong, Lushen Li, Marian Ackun-Farmmer, Lisa H. Tostanoski, Emily A. Gosselin, Alexis A. Yanes, Xiangbin Zeng, Robert S. Oakes, Jonathan S. Bromberg, Christopher M. Jewell

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