Medicine and Health

Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice

Y. Wang, Y. Xu, et al.

The COVID-19 pandemic has catalyzed breakthrough research by Yidan Wang and colleagues, introducing an innovative system of autonomous immune-like cells, known as ALICE, designed to combat viral infections. These engineered cells can detect viruses and deploy various antiviral agents, providing a promising strategy against diseases such as herpetic simplex keratitis in mice.

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Abstract

The COVID-19 pandemic highlighted the urgent need for broad-spectrum antivirals. This research engineered autonomous, intelligent, virus-inducible immune-like (ALICE) cells as sense-and-destroy antiviral systems. A destabilized STING-based sensor detects viruses, triggering expression of antiviral effectors (cytokines, CRISPR-Cas9, neutralizing antibodies). In vitro and in vivo (mouse) studies demonstrated the ALICE system's ability to inhibit viral infection, particularly a dual-output system (ALICEsaCas9+Ab) delivered via AAV, which inhibited herpetic simplex keratitis (HSK) in mice.

Publisher

Nature Communications

Published On

Dec 09, 2022

Authors

Yidan Wang, Ying Xu, Chee Wah Tan, Longliang Qiao, Wan Ni Chia, Hongyi Zhang, Qin Huang, Zhenqiang Deng, Ziwei Wang, Xi Wang, Xurui Shen, Canyu Liu, Rongjuan Pei, Yuanxiao Liu, Shuai Xue, Deqiang Kong, Danielle E. Anderson, Fengfeng Cai, Peng Zhou, Lin-Fa Wang, Haifeng Ye

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