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Commensal *Hafnia alvei* strain reduces food intake and fat mass in obese mice—a new potential probiotic for appetite and body weight management

Health and Fitness

Commensal *Hafnia alvei* strain reduces food intake and fat mass in obese mice—a new potential probiotic for appetite and body weight management

R. Legrand, N. Lucas, et al.

This exciting study reveals how *Hafnia alvei*, a ClpB-producing commensal bacterium, shows promise as a probiotic for managing appetite and body weight, potentially revolutionizing approaches to obesity treatment. The research, conducted by Romain Legrand and colleagues, uncovers significant findings through experiments on obese mice, paving the way for new probiotic interventions.

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Playback language: English
Abstract
This study investigated the potential of *Hafnia alvei*, a ClpB-producing commensal bacterium, as a probiotic for appetite and body weight management. Using *ob/ob* and high-fat diet (HFD)-fed obese mice, researchers found that chronic administration of *H. alvei* reduced body weight gain and fat mass, and decreased food intake in hyperphagic *ob/ob* mice. Elevated fat tissue levels of phosphorylated hormone-sensitive lipase were also observed. In silico analysis of human fecal metagenomes showed lower enterobacterial ClpB gene richness in obese individuals. These findings suggest *H. alvei* may be a useful probiotic for managing appetite and body weight.
Publisher
International Journal of Obesity
Published On
Jan 07, 2020
Authors
Romain Legrand, Nicolas Lucas, Manon Dominique, Saida Azhar, Camille Deroissart, Marie-Anne Le Solliec, Julie Rondeaux, Séverine Nobis, Charlène Guérin, Fatima Léon, Jean-Claude do Rego, Nicolas Pons, Emmanuelle Le Chatelier, S. Dusko Ehrlich, Gregory Lambert, Pierre Déchelotte, Sergueï O. Fetissov
Tags
Hafnia alvei
probiotic
appetite management
body weight
obesity
ClpB
hyperphagic

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