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Electrochemical C-H phosphorylation of arenes in continuous flow suitable for late-stage functionalization

Chemistry

Electrochemical C-H phosphorylation of arenes in continuous flow suitable for late-stage functionalization

H. Long, C. Huang, et al.

Discover a groundbreaking approach to C-H phosphorylation of arenes without the need for catalysts or external oxidants, developed by Hao Long, Chong Huang, Yun-Tao Zheng, Zhao-Yu Li, Liang-Hua Jie, Jinshuai Song, Shaobin Zhu, and Hai-Chao Xu. This novel electrochemical method efficiently generates C-P bonds through anodic P-radical cations, showcasing the potential for late-stage functionalization of complex molecules and impressive scalability with a continuous output of 55.0 grams of phosphonate product.

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