This paper presents a catalyst- and external oxidant-free electrochemical C-H phosphorylation reaction of arenes in continuous flow. The reaction forms C-P bonds via the reaction of arenes with anodically generated P-radical cations. This method is efficient for arenes with diverse electronic properties and enables selective late-stage functionalization of complex molecules. The continuous production of 55.0 grams of a phosphonate product demonstrates the scalability of this electrochemical approach.
