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Abstract
This paper presents a scalable flow system using immobilized enzymes for flavin-dependent biocatalysis, specifically asymmetric alkene reduction. The system integrates an Old Yellow Enzyme (OYE) and a soluble hydrogenase for H₂-driven FMNH₂ regeneration. H₂ is produced via water electrolysis. The system shows high stability and reusability, achieving >99% conversion of ketoisophorone to levodione, demonstrating versatility and selectivity in reducing various cyclic enones. This electro-driven continuous flow system has significant potential for sustainable fine chemical synthesis.
Publisher
Communications Chemistry
Published On
Sep 07, 2024
Authors
Guiyeoul Lim, Donato Calabrese, Allison Wolder, Paul R. F. Cordero, Dörte Rother, Florian F. Mulks, Caroline E. Paul, Lars Lauterbach
Tags
biocatalysis
flavin-dependent
asymmetric reduction
electrolysis
sustainable chemistry
enzymes
continuous flow system

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