Medicine and Health

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

H. He, W. Zhou, et al.

Discover a groundbreaking hemostatic cotton gauze that outperforms standard options and Combat Gauze™. This innovative gauze features a unique surface modification with a catechol compound and a long hydrophobic alkyl chain, leading to enhanced hemostatic properties and biosafety. The research was conducted by Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang, Yang Gao, Wei Chen, Wen Zhang, Yunxiang Weng, Zhengchao Wang, and Haiqing Liu.

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~3 min • Beginner • English

Index

Abstract

Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat Gauze™. Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.

Publisher

Nature Communications

Published On

Jan 27, 2022

Authors

Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang, Yang Gao, Wei Chen, Wen Zhang, Yunxiang Weng, Zhengchao Wang, Haiqing Liu

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