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Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials

Medicine and Health

Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials

S. Aquino, A. Cunha, et al.

Discover the intriguing findings of a systematic review focused on the impact of vitamin D supplementation on cardiometabolic parameters in adults with metabolic syndrome. Conducted by a team of researchers from the Federal University of Rio Grande do Norte, this study reveals significant insights into the effectiveness of vitamin D in managing metabolic health.

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~3 min • Beginner • English
Abstract
Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is effective concomitantly in controlling high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), fasting glucose level, blood pressure, and central obesity in adults diagnosed with MetS. The following scientific databases were searched from 1998 until April 2023: EMBASE, MEDLINE (PubMed), Web of Science, Latin American and Caribbean Health Sciences Literature (Lilacs), the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar. No language restrictions were applied. Seven studies were included, and they showed a high level of heterogeneity. All studies reported a significant increase in serum 25(OH)D levels in the intervention groups. Of these, only two noted a significant decrease in triglyceride (TG) level and waist circumference. However, the certainty levels of the evidence rating were very low and low for triglyceride (TG) level and waist circumference, respectively, and moderate for fasting glucose level, blood pressure, and HDL-c. In conclusion, despite these benefits, considering the low certainty, the evidence does not support that VDS decreases triglyceride (TG) level and waist circumference in adults with MetS.
Publisher
Heliyon
Published On
Oct 12, 2023
Authors
Séphora Aquino, Aline Cunha, Josivan Gomes Lima, Karine Sena-Evangelista, Antonio Gouveia Oliveira, Ricardo Ney Cobucci, Lucia Fc Pedrosa
Tags
Vitamin D
supplementation
metabolic syndrome
cardiometabolic parameters
randomized controlled trials
health
evidence synthesis
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