This systematic review and GRADE evidence synthesis investigated the effectiveness of vitamin D supplementation (VDS) in controlling cardiometabolic parameters among adults with metabolic syndrome (MetS). Seven randomized controlled trials (RCTs) were included, revealing high heterogeneity. While all studies showed increased serum 25(OH)D levels in intervention groups, only two demonstrated significant decreases in triglyceride levels and waist circumference. However, the certainty of evidence was very low for triglycerides and low for waist circumference, with moderate certainty for fasting glucose, blood pressure, and HDL-c. The evidence does not support VDS for reducing triglyceride levels and waist circumference in adults with MetS.
Publisher
Heliyon
Published On
Oct 12, 2023
Authors
Séphora Aquino, Aline Cunha, Josivan Gomes Lima, Karine Sena-Evangelista, Antonio Gouveia Oliveira, Ricardo Ney Cobucci, Lucia Fc Pedrosa
Tags
Vitamin D
supplementation
metabolic syndrome
cardiometabolic parameters
randomized controlled trials
health
evidence synthesis
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