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Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Medicine and Health

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

H. He, W. Zhou, et al.

Discover a groundbreaking hemostatic cotton gauze that outperforms standard options and Combat Gauze™. This innovative gauze features a unique surface modification with a catechol compound and a long hydrophobic alkyl chain, leading to enhanced hemostatic properties and biosafety. The research was conducted by Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang, Yang Gao, Wei Chen, Wen Zhang, Yunxiang Weng, Zhengchao Wang, and Haiqing Liu.

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Abstract
The research develops a novel hemostatic cotton gauze with superior performance compared to standard gauze and Combat Gauze™. The gauze's surface is modified with a catechol compound containing a long hydrophobic alkyl chain, enhancing its hemostatic properties, biosafety, and tissue adhesion. The improved hemostasis is attributed to the rapid formation of large primary erythrocyte clots due to controlled blood movement. This is achieved by blocking blood seepage through tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect of the alkyl chains.
Publisher
Nature Communications
Published On
Jan 27, 2022
Authors
Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang, Yang Gao, Wei Chen, Wen Zhang, Yunxiang Weng, Zhengchao Wang, Haiqing Liu
Tags
hemostatic gauze
catechol compound
tissue adhesion
erythrocyte clots
biosafety
hydrophobic alkyl chain
blood wicking

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