This study investigated the impact of simulated microgravity on the antidiabetic and antioxidant properties of wheatgrass (*Triticum aestivum*) in streptozotocin-induced diabetic rats. Wheatgrass seeds were germinated under simulated microgravity using a 3D clinostat and compared to those grown under normal gravity. Ethanolic extracts were analyzed for antioxidant activity and antidiabetic effects by assessing plasma glucose, insulin, C-peptide, HbA1c levels, β-cell count, glucose tolerance, lipid profile, and liver function. Microgravity-grown wheatgrass demonstrated significantly enhanced antioxidant potential and reduced several diabetic markers in rats, suggesting its promise as a potential treatment.

Wajdy J. Al-Awaida, Ahmad S. Sharab, Hamzeh J. Al-Ameer, Nabil Y. Ayoub