Medicine and Health

Economic choice between remifentanil and food in squirrel monkeys

S. O. Brown, D. P. Effinger, et al.

This innovative study, conducted by Samantha O. Brown and colleagues, establishes a high-throughput economic choice procedure in squirrel monkeys, unlocking insights into their preferences between remifentanil and tasty food. Through sophisticated parametric variations and rapid drug clearance, the research highlights the economic nature of their choices and the effects of pharmacological shifts on behavior.

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Abstract

This study establishes a high-throughput economic choice procedure in squirrel monkeys, allowing for the investigation of reward preference between remifentanil and a palatable food reward. The procedure uses a touchscreen apparatus where the amount of each reward is varied parametrically. The rapid clearance of remifentanil avoids confounding drug accumulation. Logistic regression is used to estimate indifference values, which are sensitive to reward devaluation and provide a useful metric for determining shifts in reward preference. The study demonstrates the economic nature of choices made by the monkeys and assesses the impact of pharmacological manipulations on choice behavior.

Publisher

Neuropsychopharmacology

Published On

Apr 08, 2021

Authors

Samantha O. Brown, Devin P. Effinger, Rodrigo A. Montoro, Nabil Daddaoua, Zuzana Justinova, Megan J. Moerke, Charles W. Schindler, Hank P. Jedema, Charles W. Bradberry

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