Biology

A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

A. Malita, O. Kubrak, et al.

Discover how gut-derived neuropeptide F (NPF) shapes dietary choices in female Drosophila! This research, conducted by Alina Malita and colleagues at the University of Copenhagen, unveils the crucial role of NPF in regulating sugar satiety and enhancing protein-rich food consumption, specifically in mated females. Unravel the secrets of appetite modulation and nutrient homeostasis!

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Abstract

Animals adapt dietary choices to meet nutritional needs. This study shows that enteroendocrine cells in adult female Drosophila midguts sense nutrients and release neuropeptide F (NPF), an ortholog of mammalian neuropeptide Y-family hormones. Gut-derived NPF, acting on glucagon-like adipokinetic hormone (AKH) signaling, induces sugar satiety and increases protein-rich food consumption. NPF suppression leads to sugar overconsumption and decreased protein intake. Gut-derived NPF also plays a female-specific role in promoting protein consumption in mated females. The findings suggest that gut NPF-to-AKH signaling modulates appetites and regulates food choice for homeostatic nutrient consumption.

Publisher

Nature Metabolism

Published On

Nov 07, 2022

Authors

Alina Malita, Olga Kubrak, Takashi Koyama, Nadja Ahrentløv, Michael J. Texada, Stanislav Nagy, Kenneth V. Halberg, Kim Rewitz

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