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Dysregulation of bile acids increases the risk for preterm birth in pregnant women

Medicine and Health

Dysregulation of bile acids increases the risk for preterm birth in pregnant women

S. You, A. Cui, et al.

This groundbreaking study reveals a direct correlation between bile acids and preterm birth (PTB), a leading cause of infant mortality. Conducted by a team of experts including Sangmin You and Ai-Min Cui, the research demonstrates how restoring bile acid balance can dramatically reduce PTB rates and improve newborn survival, opening doors to new therapeutic strategies.

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Playback language: English
Abstract
Preterm birth (PTB) is a leading cause of infant mortality. This study investigated the link between bile acids and PTB. A cohort study of 36,755 pregnant women showed a direct correlation between serum total bile acid (sTBA) levels and PTB rates. Mouse models with liver injuries and dysregulated bile acids reproduced PTB. Bile acids dose-dependently induced PTB, and restoring bile acid homeostasis reduced PTB and improved newborn survival. These findings establish a causal link between bile acids and PTB, suggesting new therapeutic avenues.
Publisher
Nature Communications
Published On
Apr 30, 2020
Authors
Sangmin You, Ai-Min Cui, Syed F. Hashmi, Xinmu Zhang, Christina Nadolny, Yuan Chen, Qiwen Chen, Xin Bush, Zachary Hurd, Winifer Ali, Gang Qin, Ruitang Deng
Tags
preterm birth
bile acids
infant mortality
serum total bile acid
newborn survival

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