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Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants

Medicine and Health

Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants

M. S. Rahman, E. Harrison, et al.

This study examined over 21,000 individuals, revealing that the APOE genotype has minimal influence on cognitive performance. Discover how distinct cognitive domains are shaped by unique genetic factors, separate from dementia risk. Conducted by leading researchers including Md Shafiqur Rahman and Emma Harrison, this research offers significant insights for future studies on neurodegenerative disorders.

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Playback language: English
Abstract
This study cognitively profiled 21,051 individuals (aged 17–85) from the Genes and Cognition cohort within the NIHR BioResource. The APOE genotype showed negligible impact on cognitive performance at scale. Different cognitive domains exhibited distinct genetic architectures, suggesting molecular and cellular mechanisms separate from dementia risk loci. The cohort is valuable for natural history and interventional studies of neurodegenerative and other disorders.
Publisher
Nature Medicine
Published On
Jun 14, 2024
Authors
Md Shafiqur Rahman, Emma Harrison, Heather Biggs, Chloe Seikus, Paul Elliott, Gerome Breen, Nathalie Kingston, John R. Bradley, Steven M. Hill, Brian D. M. Tom, Patrick F. Chinnery
Tags
cognitive performance
APOE genotype
genetic architecture
neurodegenerative disorders
dementia risk
cognitive domains

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