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Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk

Medicine and Health

Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk

A. Kishtgari, M. A. W. Khan, et al.

This groundbreaking study explores how the zygosity of CHIP mutations influences the risk of hematologic malignancies. Conducted by Ashwin Kishtgari and colleagues, it reveals that individuals with concurrent somatic mutations and mosaic chromosomal alterations face significantly heightened risk, especially those with a homozygous JAK2 V617F mutation. This research emphasizes the critical need to assess mutation zygosity in clonal hematopoiesis risk evaluation.

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~3 min • Beginner • English
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