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Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Medicine and Health

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Z. Fang, M. Fan, et al.

Explore the groundbreaking study by Zhipeng Fang and colleagues that reveals the role of hepatic lncRNA Gm19619 in glucose and lipid metabolism. This research uncovers how Gm19619, repressed by vertical sleeve gastrectomy yet upregulated by obesity and fasting, influences gluconeogenesis and lipid accumulation in the liver.

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Playback language: English
Abstract
This study identifies hepatic lncRNA Gm19619, repressed by vertical sleeve gastrectomy (VSG) but upregulated by obesity and fasting. Forced Gm19619 expression promotes gluconeogenesis, while its knockdown improves glucose and lipid metabolism. Gm19619 modulates Lepr and Foxo1 transcription, suggesting it enhances gluconeogenesis and lipid accumulation.
Publisher
Communications Biology
Published On
Jan 27, 2023
Authors
Zhipeng Fang, Mingjie Fan, Dongqiang Yuan, Lihua Jin, Yangmeng Wang, Lili Ding, Senlin Xu, Jui Tu, Eryun Zhang, Xiwei Wu, Zhen Bouman Chen, Wendong Huang
Tags
lncRNA
Gm19619
gluconeogenesis
lipid metabolism
vertical sleeve gastrectomy
obesity
fasting

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