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Abstract
This study identifies hepatic lncRNA Gm19619, repressed by vertical sleeve gastrectomy (VSG) but upregulated by obesity and fasting. Forced Gm19619 expression promotes gluconeogenesis, while its knockdown improves glucose and lipid metabolism. Gm19619 modulates Lepr and Foxo1 transcription, suggesting it enhances gluconeogenesis and lipid accumulation.
Publisher
Communications Biology
Published On
Jan 27, 2023
Authors
Zhipeng Fang, Mingjie Fan, Dongqiang Yuan, Lihua Jin, Yangmeng Wang, Lili Ding, Senlin Xu, Jui Tu, Eryun Zhang, Xiwei Wu, Zhen Bouman Chen, Wendong Huang
Tags
lncRNA
Gm19619
gluconeogenesis
lipid metabolism
vertical sleeve gastrectomy
obesity
fasting

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