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Does the SARS-CoV-2 Spike Receptor-Binding Domain Hamper the Amyloid Transformation of Alpha-Synuclein after All?

Biology

Does the SARS-CoV-2 Spike Receptor-Binding Domain Hamper the Amyloid Transformation of Alpha-Synuclein after All?

Y. Stroylova, A. Konstantinova, et al.

This groundbreaking research conducted by Yulia Stroylova and colleagues unveils an intriguing interaction between the SARS-CoV-2 spike protein's receptor-binding domain and alpha-synuclein, potentially linking COVID-19 to neurodegenerative processes. The study suggests that the receptor-binding domain may surprisingly inhibit alpha-synuclein amyloid transformation, reducing its cytotoxicity and hinting at new therapeutic avenues for Parkinson's disease.

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