Medicine and Health

Divergent effects of ketogenic and vegan diets on human immunity, metabolism, and the gut microbiome

V. M. Link, K. D. Hall, et al.

This groundbreaking study by Verena M. Link, Kevin D. Hall, and Yasmine Belkaid explores the striking effects of ketogenic and vegan diets on human immunity, metabolism, and the gut microbiome. With surprising insights into how each diet influences innate and adaptive immunity, these findings pave the way for diet-based therapeutic strategies in disease prevention and treatment.

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Playback language: English

Index

Abstract

This study investigated the impact of ketogenic and vegan diets on human immunity, metabolism, and the gut microbiome. A highly controlled crossover study involving 20 participants sequentially consumed each diet for two weeks. Multi-omics analysis revealed striking remodeling of host immunity and the microbiome, with divergent effects between the diets. Ketogenic diets enhanced adaptive immunity, while vegan diets increased innate immunity. The ketogenic diet had a broader impact on the proteome and microbiome, while both diets significantly altered host metabolism. These findings suggest diet's potential as a therapeutic tool for disease prevention and treatment.

Publisher

Nature Medicine

Published On

Feb 14, 2024

Authors

Verena M. Link, Kevin D. Hall, Yasmine Belkaid

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