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An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species

Biology

An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species

S. Leviatan, S. Shoer, et al.

This groundbreaking research conducted by Sigal Leviatan, Saar Shoer, Daphna Rothschild, Maria Gorodetski, and Eran Segal reveals a new reference set of 3,594 high-quality species genomes derived from the human gut microbiome, incorporating 310 novel species and showcasing the remarkable diversity yet to be explored.

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Playback language: English
Abstract
This study expands the human gut microbiome reference map by combining new microbial metagenomic assembled genomes from 51,052 samples with previously published genomes. A curated set of 241,118 genomes resulted in a new reference set of 3594 high-quality species genomes, matching 83.65% of validation samples' reads. This improved reference set includes 310 novel species, highlighting the previously unknown diversity within the human gut microbiome.
Publisher
Nature Communications
Published On
Jul 05, 2022
Authors
Sigal Leviatan, Saar Shoer, Daphna Rothschild, Maria Gorodetski, Eran Segal
Tags
human gut microbiome
microbial metagenomics
reference genomes
novel species
genomic diversity
metagenomic assembled genomes
validation samples

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