Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction

This study investigated the effects of dietary biogenic selenium nanoparticles (SeNPs) supplementation on oxidative stress-induced intestinal barrier dysfunction in mice. Selenium deficiency caused redox imbalance, inflammation, gut microbiota dysbiosis, and mitochondrial dysfunction, leading to intestinal barrier injury. SeNPs supplementation alleviated diquat-induced intestinal barrier dysfunction by enhancing antioxidant capacity, inhibiting ROS overproduction, protecting mitochondrial function, regulating immune response, and maintaining gut microbiota homeostasis via the Nrf2-mediated NLRP3 signaling pathway. Fecal microbiota transplantation further confirmed the role of SeNPs-modulated gut microbiota in protecting against intestinal dysfunction. Dietary SeNPs supplementation prevents oxidative stress-induced intestinal barrier dysfunction through mitochondria and gut microbiota regulation.

Lei Qiao, Xinyi Zhang, Shanyao Pi, Jiajing Chang, Xina Dou, Shuqi Yan, Xiaofan Song, Yue Chen, Xiaonan Zeng, Lixu Zhu, Chunlan Xu