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Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

Psychology

Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

E. Lee, J. Park, et al.

Discover how chronic stress and glucocorticoids interact in surprising ways to alleviate stress-induced depressive-like behavior in mice. Research by Eun-Hwa Lee and colleagues reveals that a simple five-minute stress resolution technique can reverse mood disorders, illuminating complex neural pathways. Dive into the science behind this innovative approach!

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Playback language: English
Abstract
Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. This study demonstrates that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated low-dose glucocorticoid injections mimic these anti-depressive effects. Both repeated short-term stress and glucocorticoid injections activate neurons in overlapping brain regions and reverse stress-induced gene expression. Chemogenetic inhibition of specific prefrontal cortex neuronal projections also shows anti-depressive effects, suggesting a complex interplay of neural pathways in mediating the response to stress.
Publisher
Nature Communications
Published On
Nov 18, 2021
Authors
Eun-Hwa Lee, Jin-Young Park, Hye-Jin Kwon, Pyung-Lim Han
Tags
chronic stress
glucocorticoids
depressive-like behavior
neural pathways
prefrontal cortex
chemogenetic inhibition
gene expression

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