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Abstract
Conflicting data exists on the role of branched-chain amino acids (BCAAs) in metabolic health. This study investigated the individual effects of leucine and valine in mice fed high-fat diets. Leucine supplementation showed beneficial effects on adiposity and insulin sensitivity, while valine worsened high-fat diet-induced health impairments, reducing glucose tolerance and insulin sensitivity due to increased 3-hydroxyisobutyrate (3-HIB) levels, which increased basal skeletal muscle glucose uptake, leading to glucotoxicity and impaired myocyte insulin signaling.
Publisher
Nutrition and Diabetes
Published On
Apr 13, 2022
Authors
Christopher A. Bishop, Tina Machate, Thorsten Henning, Janin Henkel, Gerhard Püschel, Daniela Weber, Tilman Grune, Susanne Klaus, Karolin Weitkunat
Tags
branched-chain amino acids
leucine
valine
metabolic health
insulin sensitivity
glucose tolerance

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