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Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Medicine and Health

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

D. Duffy

This groundbreaking study by Darragh Duffy uncovers the vital role of type I interferons in COVID-19 severity, revealing that diminished IFN-I responses correlate with worsened disease outcomes. With sensitive assays highlighting impaired IFN-I induction in hospitalized patients, the research sheds light on why current IFN-I treatments may falter late in the infection, paving the way for innovative therapeutic strategies.

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