Medicine and Health

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

D. Duffy

This groundbreaking study by Darragh Duffy uncovers the vital role of type I interferons in COVID-19 severity, revealing that diminished IFN-I responses correlate with worsened disease outcomes. With sensitive assays highlighting impaired IFN-I induction in hospitalized patients, the research sheds light on why current IFN-I treatments may falter late in the infection, paving the way for innovative therapeutic strategies.

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Abstract

This study investigates the role of type I interferons (IFN-I) in COVID-19 severity. Researchers found that reduced IFN-I responses are consistently associated with increased disease severity. They highlight the importance of using sensitive assays to measure IFN-I proteins and show that hospitalized patients exhibit impaired IFN-I induction upon immune stimulation, not solely due to autoantibodies. The study suggests that this impaired IFN-I response may explain the poor clinical response to IFN-I-based treatments in late-stage COVID-19 and proposes alternative therapeutic strategies.

Publisher

Nature Communications

Published On

Nov 25, 2022

Authors

Darragh Duffy

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