Medicine and Health

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas

H. Robertson, H. J. Kim, et al.

This groundbreaking study by Harry Robertson and colleagues investigates human pan-organ allograft dysfunction across diverse transplant types, revealing key genes linked to dysfunction and introducing an innovative transfer learning framework that shows promise for improving patient outcomes. The research, validated with a kidney transplant cohort, highlights significant advancements in clinical applications.

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Abstract

This study presents a comprehensive analysis of human pan-organ allograft dysfunction using 150 datasets with over 12,000 samples across heart, lung, liver, and kidney transplants. The researchers identified genes robustly correlated with allograft dysfunction across all organs and developed a transfer learning omics prediction framework that outperformed single-organ models. These findings were validated using a prospective kidney transplant cohort, suggesting potential clinical utility.

Publisher

Nature Medicine

Published On

Dec 01, 2024

Authors

Harry Robertson, Hani Jieun Kim, Jennifer Li, Nicholas Robertson, Paul Robertson, Elvira Jimenez-Vera, Farhan Ameen, Andy Tran, Katie Trinh, Philip J. O'Connell, Jean Y. H. Yang, Natasha M. Rogers, Ellis Patrick

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