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Deciphering intercellular signaling complexes by interaction-guided chemical proteomics

Chemistry

Deciphering intercellular signaling complexes by interaction-guided chemical proteomics

J. Zheng, Z. Zheng, et al.

This groundbreaking research by Jiangnan Zheng and colleagues introduces a novel interaction-guided crosslinking (IGC) chemical proteomics approach to identify critical ligand-receptor interactions in situ. By utilizing glycan-based ligation and click chemistry, the team unravels a new interaction between pancreatic cancer cell-secreted urokinase and neuropilin 1, paving the way for further exploration of intercellular signaling mechanisms.... show more
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Citations
22
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57
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