CRISPR-Cas-amplified urinary biomarkers for multiplexed and | ResearchBunny

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Abstract

This research introduces chemically stabilized nucleic acids to multiplex synthetic biomarkers, enabling the detection and differentiation of disease states in murine cancer models through non-invasive urine analysis. The method employs microenvironmental endopeptidase to trigger barcode release and CRISPR-Cas-mediated detection, culminating in a point-of-care paper diagnostic tool and a microfluidic platform for high-throughput analysis.

Publisher

Nature Nanotechnology

Published On

Apr 24, 2023

Authors

Liangliang Hao, Renee T. Zhao, Nicole L. Welch, Edward Kah Wei Tan, Qian Zhong, Nour Saida Harzallah, Chayanon Ngambenjawong, Henry Ko, Heather E. Fleming, Pardis C. Sabeti, Sangeeta N. Bhatia

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