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Abstract
Pancreatic cancer is a lethal disease with limited effective blood-based biomarkers for monitoring treatment response. This study investigated the use of circulating tumor DNA (ctDNA) as a prognostic marker and for monitoring treatment response in advanced pancreatic cancer. Comprehensive ctDNA measurement, combining mutation detection in eight genes and copy number variation analysis, improved prediction of clinical outcomes and enabled dynamic tracking of disease progression. ctDNA persistence after chemotherapy initiation was associated with shorter survival, and ctDNA surveillance provided a median 19-day lead time in detecting progression compared to 6 days for CA19-9. Despite limitations in sensitivity, ctDNA increases during longitudinal monitoring were highly specific to disease progression.
Publisher
CLINICAL CANCER RESEARCH | PRECISION MEDICINE AND IMAGING
Published On
Apr 01, 2023
Authors
Morten Lapin, Karin H Edland, Kjersti Tjensvoll, Satu Oltedal, Marie Austdal, Herish Garresori, Yves Rozenholc, Bjørnar Gilje, Oddmund Nordgård
Tags
pancreatic cancer
circulating tumor DNA
ctDNA
treatment response
prognostic marker
disease progression

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