Medicine and Health

Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer

M. Lapin, K. H. Edland, et al.

This study, conducted by Morten Lapin and colleagues at Stavanger University Hospital, explores the potential of circulating tumor DNA (ctDNA) as a prognostic marker in advanced pancreatic cancer. With improved prediction of clinical outcomes and a significant lead time in tracking disease progression, ctDNA presents a promising avenue for enhancing treatment monitoring.

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Abstract

Pancreatic cancer is a lethal disease with limited effective blood-based biomarkers for monitoring treatment response. This study investigated the use of circulating tumor DNA (ctDNA) as a prognostic marker and for monitoring treatment response in advanced pancreatic cancer. Comprehensive ctDNA measurement, combining mutation detection in eight genes and copy number variation analysis, improved prediction of clinical outcomes and enabled dynamic tracking of disease progression. ctDNA persistence after chemotherapy initiation was associated with shorter survival, and ctDNA surveillance provided a median 19-day lead time in detecting progression compared to 6 days for CA19-9. Despite limitations in sensitivity, ctDNA increases during longitudinal monitoring were highly specific to disease progression.

Publisher

CLINICAL CANCER RESEARCH | PRECISION MEDICINE AND IMAGING

Published On

Apr 01, 2023

Authors

Morten Lapin, Karin H Edland, Kjersti Tjensvoll, Satu Oltedal, Marie Austdal, Herish Garresori, Yves Rozenholc, Bjørnar Gilje, Oddmund Nordgård

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