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Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer

Medicine and Health

Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer

M. Lapin, K. H. Edland, et al.

This study, conducted by Morten Lapin and colleagues at Stavanger University Hospital, explores the potential of circulating tumor DNA (ctDNA) as a prognostic marker in advanced pancreatic cancer. With improved prediction of clinical outcomes and a significant lead time in tracking disease progression, ctDNA presents a promising avenue for enhancing treatment monitoring.

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~3 min • Beginner • English
Abstract
The only blood-based biomarker routinely used to monitor pancreatic cancer, CA19-9, has significant limitations. Circulating tumor DNA (ctDNA) offers a promising alternative. This study shows that ctDNA can monitor treatment response and tumor progression in advanced pancreatic cancer. Persistence of ctDNA after treatment initiation is associated with high probability of progression and poorer survival. During follow-up, ctDNA identified disease progression with a median lead time of 19 days relative to radiological imaging/time of death, versus 6 days for CA19-9. Prospective interventional trials are needed to translate these findings into clinical practice and improve patient outcomes.
Publisher
CLINICAL CANCER RESEARCH | PRECISION MEDICINE AND IMAGING
Published On
Apr 01, 2023
Authors
Morten Lapin, Karin H Edland, Kjersti Tjensvoll, Satu Oltedal, Marie Austdal, Herish Garresori, Yves Rozenholc, Bjørnar Gilje, Oddmund Nordgård
DOI
https://doi.org/https://doi.org/10.1158/1078-0432.ccr-22-3526
Tags
pancreatic cancer
circulating tumor DNA
ctDNA
treatment response
prognostic marker
disease progression

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