Medicine and Health

Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta's Tomorrow Project

D. E. O'sullivan, A. Metcalfe, et al.

This pioneering research identifies unique lifestyle behaviour clusters and their impact on colorectal cancer risk, revealing alarming findings such as high-risk groups experiencing a CRC risk up to 2.87 times greater than low-risk ones. Conducted by Dylan E. O'Sullivan and colleagues, this study emphasizes the importance of targeted prevention strategies.

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Playback language: English

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Abstract

This study aimed to identify distinct clusters of individuals exhibiting unique patterns of modifiable lifestyle behaviours and their association with colorectal cancer (CRC) risk. Using data from Alberta's Tomorrow Project (26,460 participants, 267 CRC cases), latent class analysis of six risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit/vegetable consumption) and Cox proportional hazard models were employed. Seven unique behavioural groups were identified, with high-risk groups showing a 2.34 to 2.87 times greater CRC risk compared to the low-risk group. Sex-specific models revealed higher risks among men (HRs: 3.15 to 3.89) than women (HRs: 1.99 to 2.19). Targeting these behaviourally defined groups could improve CRC prevention.

Publisher

Scientific Reports

Published On

Nov 25, 2020

Authors

Dylan E. O'Sullivan, Amy Metcalfe, Troy W. R. Hillier, Will D. King, Sangmin Lee, Joy Paders, Darren R. Brenner

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