This study investigates the enhanced cancer risk in companion animals due to increased longevity. Using a multi-step cancer model, the authors show that environmental improvements leading to longer lifespans increase cancer prevalence in the short term, even without changes in genomic error rates. However, in the long term, evolution favors lower genomic error rates, mitigating cancer risk. The model explores the interplay between short-term (non-evolutionary) and long-term (evolutionary) responses to environmental changes.
Publisher
Scientific Reports
Published On
Nov 11, 2020
Authors
Moeko Tanaka, Sachi Yamaguchi, Yoh Iwasa
Tags
cancer risk
companion animals
longevity
environmental improvements
genomic error rates
evolution
multi-step model
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