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Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant *Klebsiella pneumoniae*

Medicine and Health

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant *Klebsiella pneumoniae*

A. Eskenazi, C. Lood, et al.

A groundbreaking study reveals the successful treatment of a 30-year-old bombing victim suffering from a pandrug-resistant *Klebsiella pneumoniae* infection. Using a novel combination of pre-adapted bacteriophage therapy alongside antibiotics, this research conducted by authors from various esteemed institutions demonstrates significant clinical and microbiological improvements. Discover how this innovative approach is reshaping the fight against antibiotic resistance!

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Playback language: English
Abstract
A 30-year-old bombing victim with a fracture-related pandrug-resistant *Klebsiella pneumoniae* infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient's wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient's *K. pneumoniae* strain *in vitro*, in 7-day mature biofilms and in suspensions.
Publisher
Nature Communications
Published On
Jan 18, 2022
Authors
Anaïs Eskenazi, Cédric Lood, Julia Wubbolts, Maya Hites, Nana Balarjishvili, Lika Leshkasheli, Lia Askilashvili, Leila Kvachadze, Vera van Noort, Jeroen Wagemans, Marc Jayankura, Nina Chanishvili, Mark de Boer, Peter Nibbering, Mzia Kutateladze, Rob Lavigne, Maya Merabishvili, Jean-Paul Pirnay
Tags
bacteriophage therapy
Klebsiella pneumoniae
pandrug-resistant
antibiotic resistance
clinical improvement
infection treatment

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