A 30-year-old bombing victim with a fracture-related pandrug-resistant *Klebsiella pneumoniae* infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient's wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient's *K. pneumoniae* strain *in vitro*, in 7-day mature biofilms and in suspensions.
Publisher
Nature Communications
Published On
Jan 18, 2022
Authors
Anaïs Eskenazi, Cédric Lood, Julia Wubbolts, Maya Hites, Nana Balarjishvili, Lika Leshkasheli, Lia Askilashvili, Leila Kvachadze, Vera van Noort, Jeroen Wagemans, Marc Jayankura, Nina Chanishvili, Mark de Boer, Peter Nibbering, Mzia Kutateladze, Rob Lavigne, Maya Merabishvili, Jean-Paul Pirnay
Tags
bacteriophage therapy
Klebsiella pneumoniae
pandrug-resistant
antibiotic resistance
clinical improvement
infection treatment
Related Publications
Explore these studies to deepen your understanding of the subject.
