Coacervation in polyzwitterion-polyelectrolyte systems and their

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Abstract

This research introduces poly-zwitterionic complexes (pZCs), formed by liquid-liquid phase separation of a polyzwitterion and a polyelectrolyte. The pZCs exhibit orthogonal phase behavior, remaining intact in acidic conditions but disassembling as pH increases. This behavior is linked to gastrointestinal conditions, demonstrating the potential of pZCs as pH-triggered drug delivery systems for enhanced oral drug uptake efficiency.

Publisher

Nature Communications

Published On

Apr 26, 2022

Authors

Khatcher O. Margossian, Marcel U. Brown, Todd Emrick, Murugappan Muthukumar

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