Medicine and Health

Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms

K. O. Margossian, M. U. Brown, et al.

This research introduces poly-zwitterionic complexes (pZCs) that can revolutionize drug delivery by exhibiting unique pH-responsive behavior, making them ideal for enhanced oral drug uptake. Conducted by Khatcher O. Margossian, Marcel U. Brown, Todd Emrick, and Murugappan Muthukumar, this study explores their potential in gastrointestinal conditions.

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Abstract

This research introduces poly-zwitterionic complexes (pZCs), formed by liquid-liquid phase separation of a polyzwitterion and a polyelectrolyte. The pZCs exhibit orthogonal phase behavior, remaining intact in acidic conditions but disassembling as pH increases. This behavior is linked to gastrointestinal conditions, demonstrating the potential of pZCs as pH-triggered drug delivery systems for enhanced oral drug uptake efficiency.

Publisher

Nature Communications

Published On

Apr 26, 2022

Authors

Khatcher O. Margossian, Marcel U. Brown, Todd Emrick, Murugappan Muthukumar

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