Chemotaxis-driven delivery of nano-pathogenoids for complete

Index

Abstract

This research introduces a nano-pathogenoid (NPN) system that overcomes biological barriers in nano-mediated drug delivery, enhancing the efficacy of photothermal therapy (PTT). NPNs, cloaked in bacteria-secreted outer membrane vesicles, are internalized by neutrophils, which migrate to inflamed tumors. NPNs are released from neutrophils in response to inflammatory stimuli and taken up by tumor cells, leading to complete tumor eradication in mice when combined with PTT and cisplatin.

Publisher

NATURE COMMUNICATIONS

Published On

Feb 28, 2020

Authors

Min Li, Shuya Li, Han Zhou, Xinfeng Tang, Yi Wu, Wei Jiang, Zhigang Tian, Xuechang Zhou, Xianzhu Yang, Yucai Wang

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