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Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Medicine and Health

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Y. Zheng, R. Ye, et al.

This groundbreaking research by Ying Zheng and team introduces a wearable microneedle patch that harnesses iontophoresis for efficient vaccine delivery, outperforming traditional methods. The user-friendly, low-cost system promises a new era of at-home vaccine self-administration, potentially transforming public health.

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Playback language: English
Abstract
This paper presents a novel wearable iontophoresis-driven microneedle (MN) patch for efficient transdermal delivery of vaccine macromolecules. The patch utilizes a polyacrylamide/chitosan hydrogel with high biocompatibility, conductivity, and elasticity to store and deliver the vaccine. Microneedles puncture the stratum corneum, creating microchannels, while iontophoresis actively drives the vaccine through these channels. In vitro and in vivo studies demonstrate that this system effectively delivers ovalbumin, inducing a stronger immune response than intramuscular injection. The system is low-cost and user-friendly, promising for at-home vaccine self-administration.
Publisher
Microsystems & Nanotechnology
Published On
Nov 16, 2023
Authors
Ying Zheng, Rui Ye, Xia Gong, Jingbo Yang, Bin Liu, Yunsheng Xu, Gang Nie, Xi Xie, Lelun Jiang
Tags
wearable technology
microneedles
iontophoresis
vaccine delivery
immune response

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