logo
ResearchBunny Logo
Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Medicine and Health

Iontophoresis-driven microneedle patch for the active transdermal delivery of vaccine macromolecules

Y. Zheng, R. Ye, et al.

This groundbreaking research by Ying Zheng and team introduces a wearable microneedle patch that harnesses iontophoresis for efficient vaccine delivery, outperforming traditional methods. The user-friendly, low-cost system promises a new era of at-home vaccine self-administration, potentially transforming public health.

00:00
00:00
Playback language: English
Abstract
This paper presents a novel wearable iontophoresis-driven microneedle (MN) patch for efficient transdermal delivery of vaccine macromolecules. The patch utilizes a polyacrylamide/chitosan hydrogel with high biocompatibility, conductivity, and elasticity to store and deliver the vaccine. Microneedles puncture the stratum corneum, creating microchannels, while iontophoresis actively drives the vaccine through these channels. In vitro and in vivo studies demonstrate that this system effectively delivers ovalbumin, inducing a stronger immune response than intramuscular injection. The system is low-cost and user-friendly, promising for at-home vaccine self-administration.
Publisher
Microsystems & Nanotechnology
Published On
Nov 16, 2023
Authors
Ying Zheng, Rui Ye, Xia Gong, Jingbo Yang, Bin Liu, Yunsheng Xu, Gang Nie, Xi Xie, Lelun Jiang
Tags
wearable technology
microneedles
iontophoresis
vaccine delivery
immune response

Related Publications

Explore these studies to deepen your understanding of the subject.

Investigating the Role of Context in the Delivery of Text Messages for Supporting Psychological Wellbeing
Computer Science

Investigating the Role of Context in the Delivery of Text Messages for Supporting Psychological Wellbeing

A. Bhattacharjee, J. J. Williams, et al.

Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds
Chemistry

Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

M. Kondo, H. D. P. Wathsala, et al.

Development of spirulina for the manufacture and oral delivery of protein therapeutics
Medicine and Health

Development of spirulina for the manufacture and oral delivery of protein therapeutics

B. W. Jester, H. Zhao, et al.

Identification of active catalysts for the acceptorless dehydrogenation of alcohols to carbonyls
Chemistry

Identification of active catalysts for the acceptorless dehydrogenation of alcohols to carbonyls

T. Wang, J. Sha, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny