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Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Medicine and Health

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

M. Li, S. Li, et al.

This groundbreaking research by Min Li and colleagues unveils a revolutionary nano-pathogenoid system that transcends biological barriers in drug delivery, significantly boosting the power of photothermal therapy against tumors. Their innovative approach offers complete tumor eradication in mice with a combination of therapies, paving the way for advanced cancer treatments.

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Playback language: English
Abstract
This research introduces a nano-pathogenoid (NPN) system that overcomes biological barriers in nano-mediated drug delivery, enhancing the efficacy of photothermal therapy (PTT). NPNs, cloaked in bacteria-secreted outer membrane vesicles, are internalized by neutrophils, which migrate to inflamed tumors. NPNs are released from neutrophils in response to inflammatory stimuli and taken up by tumor cells, leading to complete tumor eradication in mice when combined with PTT and cisplatin.
Publisher
NATURE COMMUNICATIONS
Published On
Feb 28, 2020
Authors
Min Li, Shuya Li, Han Zhou, Xinfeng Tang, Yi Wu, Wei Jiang, Zhigang Tian, Xuechang Zhou, Xianzhu Yang, Yucai Wang
Tags
nano-pathogenoid
drug delivery
photothermal therapy
tumor eradication
inflammatory stimuli

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