Medicine and Health

Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice

M. Li, L. Li, et al.

Discover the groundbreaking findings from researchers Min Li and colleagues, revealing how gut microbiota deficient mice exhibit faster glucose clearance. This study uncovers the critical roles of brown adipose tissue and cecum in glucose uptake, challenging our understanding of metabolic processes.

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Abstract

Gut microbiota deficient mice demonstrate accelerated glucose clearance. This study investigates glucose uptake in 22 tissues across three mouse models to determine the tissues responsible for this enhanced uptake. Results indicate that brown adipose tissue (BAT) and cecum contribute significantly, independent of adaptive thermogenesis and UCP1 expression. Deletion of UCP1-expressing cells blunts the improvement in glucose clearance, highlighting BAT's crucial role in glucose uptake in microbiota-depleted mice.

Publisher

Nature Communications

Published On

Aug 05, 2021

Authors

Min Li, Li Li, Baoguo Li, Catherine Hambly, Guanlin Wang, Yingga Wu, Zengguang Jin, Anyongqi Wang, Chaoqun Niu, Christian Wolfrum, John R. Speakman

DOI

https://doi.org/10.1038/s41467-021-24659-8

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