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Abstract
Using X-ray crystallography, the researchers determined the structure of a polyhedrin from Nudiviridae, a double-stranded DNA virus family related to baculoviruses. A 70-year-old sample revealed a well-ordered lattice formed by a predominantly α-helical protein building block, assembling into a dense, interconnected crystal. The lattice's stability stems from hydrophobic and electrostatic interactions, disulfide bonds, and domain switching, resisting environmental stresses. While distinct from baculovirus or cypovirus polyhedra in structure, space group, and unit cell dimensions, it shares common occlusion body assembly principles.
Publisher
Nature Communications
Published On
Jul 13, 2023
Authors
Jeremy R. Keown, Adam D. Crawshaw, Jose Trincao, Loïc Carrique, Richard J. Gildea, Sam Horrell, Anna J. Warren, Danny Axford, Robin Owen, Gwyndaf Evans, Annie Bézier, Peter Metcalf, Jonathan M. Grimes
Tags
X-ray crystallography
Nudiviridae
polyhedrin
protein structure
virus family

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