This meta-analysis investigated the association between psoriasis and the risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Seven cohort studies were included, encompassing 738,104 psoriasis cases and 3,443,438 controls. Pooled analysis revealed a significantly increased risk of CKD (HR 1.65, 95% CI 1.29-2.12) and ESRD (HR 1.37, 95% CI 1.14-1.64) in psoriasis patients. Subgroup analysis indicated that the risk was higher for patients with severe psoriasis, particularly for ESRD (HR 2.72, 95% CI 1.70-4.34). Potential mechanisms discussed include inflammation, drug-related effects, and chronic renal damage. Limitations include the reliance on electronic health record databases and heterogeneity in study designs.
Publisher
Frontiers in Medicine
Published On
Jan 01, 2023
Authors
XJ, WZ, CA, HK, WP
Tags
psoriasis
chronic kidney disease
end-stage renal disease
meta-analysis
risk factors
inflammation
cohort studies
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