Psychology

Learned Nocebo Effects on Cutaneous Sensations of Pain and Itch: A Systematic Review and Meta-analysis of Experimental Behavioral Studies on Healthy Humans

M. A. Thomaidou, J. S. Blythe, et al.

Discover the intriguing world of nocebo effects, where negative treatment expectations exacerbate pain or itch sensations. This systematic review and meta-analysis, conducted by esteemed researchers including Mia A Thomaidou and Joseph S Blythe, uncovers significant findings that could reshape our understanding of patient expectations in treatment outcomes. Dive into the details!

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Playback language: English

Index

Abstract

This systematic review and meta-analysis investigated the magnitude of nocebo effects (aggravated pain or itch due to negative treatment expectations) in 37 experimental studies on healthy humans. Meta-analyses showed moderate to large effect sizes (Hedges' g between 0.26 and 0.71), with combined conditioning and verbal suggestions yielding stronger pain nocebo responses. Subgroup analyses did not explain heterogeneity, and risk of bias was low. The study recommends more consistent experimental designs and reporting.

Publisher

Psychosomatic Medicine

Published On

May 01, 2023

Authors

Mia A Thomaidou, Joseph S Blythe, Kaya J Peerdeman, Antoinette I M Van Laarhoven, Myrthe M E Van Schothorst, Dieuwke S Veldhuijzen, Andrea W M Evers

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