This multicenter cross-sectional study and meta-analysis investigated the association between fast eating and metabolic dysfunction-associated steatotic liver disease (MASLD). A cross-sectional study of 1965 Chinese adults found a significant association between frequent fast eating (≥2 times/week) and MASLD (OR, 1.29; 95%CI, 1.09–1.53). A meta-analysis of five studies confirmed this association (pooled OR, 1.22; 95%CI, 1.07–1.39). Frequent fast eating was independently associated with increased MASLD risk, even after adjusting for confounding factors.